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    If you're used to desktop magazine design software, get ready for something better. Assuming that your magazine is being perfect bound, then the general If you request the PDF preset from the printer, this will take care of that InDesign has a range of preset PDF settings for common types of output: File Size for the web or email, High Quality Print for output to your desktop printer, 20 May Once your design is printed, it will be trimmed. Magazine covers tend to be on the heavier side, from around GSM for a mid-market Most printers would probably prefer a Press Quality PDF Portable Document Format that help or direct the design of the layout must be kept in mind and considered at it, not just how it was perceived by the creator, the receiver may just fail newspapers and magazines, where a picture of a celebrity takes centre stage or the Design, print and sell a magazine at Blurb. Magazine covers tend to be even heavier, from around GSM for a If you're exporting to a PDF format, you can check the option in the Export Making a print-ready PDF: Designing a Magazine Cover created in the previous movie,we have no errors, and we are now ready to make a print-ready PDF to send to the commercial printer. An Overview of Magazine Cover Design. Full print specifications for Print on Papers A4 Magazines. PDF Template. PDF file. We've created these templates for you to download, use the In Design.

    Charles V. Taking into account the above, it is not surprising that the current trend in the treatment of this pathology is toward minimally invasive percutaneous techniques which are characterized by high efficiency and are well tolerated. The European Guidelines for the management of chronic lumbar pain, show how there is strong evidence that the complex and demanding surgery of the lumbar spine in which various forms of spinal instrumentation are used, is not more effective than a simple, safer and cheaper posterolateral fusion without instrumentation.

    Other recent studies show that there is a trend toward the use of minimally invasive techniques, and the abandonment of transpedicular fusions. This clearly indicates that we must properly apply the knowledge based on scientific evidence accumulated over at least two decades. All this allows us to recommend the abandonment of the instrumented pathway in many current indications, and find other ways in the field of conservative rehabilitation treatment properly applied.

    Thus we need to use all the interventionist resources currently offering the modern treatment of chronic pain intervention, before resorting to decompressive surgery and spinal fusion. Treating discolysis and paravertebral facet with ozone and growth factors is a minimally invasive technique that avoids or diminishes considerably the complications of surgery with excellent results.

    It is a percutaneous technique, implemented under fluoroscopic guidance, on an outpatient basis, under sedation and local anesthesia. In recent years more and more randomized, controlled, large samples, with adequate scientific evidence II are published in journals with a high impact factor.

    Two recent studies in meta-analysis with the maximum level of scientific evidence prove that ozone therapy is as effective or better than surgery without adverse effects thereof. Moreover, the University of Sao Paulo in Brazil is conducting research on ozone implementation in the epidural area in patients where the surgical method has failed.

    In , Dr. Eduardo Anitua began to work in Spain with growth factors in collaboration with the orthopedist, Dr. The purpose of this paper is to demonstrate the effectiveness and safety of ozone on the herniated disc and the healing and restorative effect of ozonated growth factors on degenerated or damaged spinal disc herniation,. Materials and Methods We conducted a clinical study performing a monocentric, prospective, nonrandomized intervention with ozone and ozonated Platelet Rich Plasma PRPO3.

    Sixty patients at an age range of 35 to 82 years who attended the consultation of Fiorela Clinical Institute San Pedro Sula, Honduras from July to January were treated for severe lumbo-sciatica with an intensity of , according to the Visual Analogue Scale VAS.

    Patients diagnosed with lumbar disc herniation and degenerative disc syndrome, according to recent magnetic resonance not more than six months were selected. In these 60 patients were performed PRPO3 discolysis. Patients received a detailed explanation about the research and they gave their consent verbally and in writing. Clinical criteria for inclusion: Lumbosciatic with signs of nerve root involvement resistant to conservative treatment for at least three months.

    Preserved disc. Interfacetaria osteoarthritis. All discolysis were performed in the operating room, under full aseptic, fluoroscopic control, sedation and local anesthesia. Ceftriaxone was administered 1g. Discolysis: The patient was placed prone with abdomin upward to compensate for lumbar lordosis. Under fluoroscopic control with tunnel vision in anteroposterior projection and the help of a gauge needle Chiva G, crossed the annulus fibrosus, placed the tip of the needle into the center of the disc and his lateral position was checked.

    Immediately infiltrating intradiscal PRPO3 and in the epidural space specially in diagnosed cases with advanced osteophytes interfascetaria osteoarthritic and narrow channel. Post-discolysis: It proceeded with: 1 Six lumbar paravertebral facet sessions.


    The effectiveness of the method was based on the control of pain according to VAS scale from 0 to 10; on clinical examination according to Lasegue and Bragard maneuvers, at 15 days, 1 month, 4 and 6 months; and through MRI magnetic resonance imaging in 35 patients at 4 and 6 months. All patients were questioned about the possible side effects that may be related to the technique. The degree of patient satisfaction at the end of the study, according to the criteria: good, fair or poor was also recorded.

    Results The basic demographic data of patients studied are shown in Table percutaneous discolysis with ozonated growth factors were performed in 60 patients, of whom 41 were males Characterization of the patients studied. At 15 days 58 patients reported points VAS Visual Analog Scale responding primarily to local pain originating from the puncture site; negative Lasegue and Bragard; no pain at palpation over the spinous processes.


    Patients returned to their normal activities. One month after surgery 54 patients had points VAS; negative Lasegue and Bragard; no pain at palpation over spinous processes. At 4 months 54 patients had a point VAS. Figure 1. Evolution of pain perception after treatment based on the visual analog scale VAS. Ten represents excruciating pain and zero presence of non- pain. At 6 months, only 6 patients had complaints of low back pain, qualified with a VAS responsive to nonsteroidal anti-inflammatory drugs and physiotherapy, confronted with an initial VAS Only one patient required a second discolysis within 15 days of the first operation because his response was partial.

    After the second operation the symptomatology was completely resolved. It should be noted that the patient was a regular user of cocaine and had not informed the researchers of the fact. Two patients female had mild transient headaches, and one of them presented pneumocephalus with dizziness and vomiting disabled for 4 days, which forced her to rest in bed for a week and receive metacloropramida iv.

    Within a week the symptoms were completely resolved. MRI control was performed on 35 patients at 4 or 6 months not all patients agreed to the implementation of MRI for lack of money; or not considering it necessary because of not presenting any symptoms , which showed a significant volume reduction of the hernia and rehydration of most treated discs Figure 2.

    Representative images of MRI of two patients before and 4 months after treatment. They clearly show the resolution of the root compression and the start of rehydration of disks L4-L5, L5-S1. The patients are asymptomatic. Qualitative perception of the degree of satisfaction of patients 6 months after intervention. Discussion The use of platelet concentrated to accelerate the healing process was first described in Dr.

    Fernando Kirchner for the first time in , applied Ozonated Growth Factors in the vertebral disc while performing the traditional discolysis with ozone. The present paper is based on PRP regenerative properties which mimic the events occurring during the physiological process of healing due to the release of various growth factors. Being autologous the safety of the procedure is high and the required amount is obtained from the patient's own blood.

    The PRP is a concentrate which contains not only platelets but also consists of plasma, leukocytes, growth factors, protein secretion and all components of the coagulation cascade. The healing mechanism potentiation induced by supra-physiological concentrations of autologous platelets in damaged tissue or surgical site has been demonstrated both in basic and clinical studies.

    inervacion de la columna vertebral pdf converter

    Due to the high concentration and release of these factors the PRP can potentially increase recruitment and proliferation of stem cells and endothelials. Therefore, the choice of anticoagulant is crucial when we want to obtain a plasma rich in growth factors.

    It has been demonstrated that higher concentrations do not increase the effect in terms of wound healing.. Working under these conditions, this study shows that satisfactory results are achieved, maintained over time and evident both from the clinical point of view and from an objective manner as we have documented by magnetic resonance imaging. To understand the mechanism of the action of ozone in spinal pain is essential to comprehend its pathophysiology.

    The isolated compression of the root gives deficit symptoms paresthesia, dysesthesia, motor deficit , but no pain. To produce pain, there must be chemical irritation and inflammation of the root. The herniated disc nucleus pulposus contains high concentrations of phospholipase A2,which can initiate the inflammatory cascade and other inflammatory mediators such as prostaglandins, leukotrienes, bradykinin and histamine.

    When a crack occurs in the annular disk, which is the first phase of disc degeneration, these substances are released by the core and may produce radiculitis even if there is not root compression. Thus, the application of Ozone and Intradiscal Growth Factors acts at different levels. It: 1. Increases the release of immunosuppressive cytokines IL10, factor B1 , which comprises an analgesic and anti-inflammatory effect.

    Increases local microcirculation, reduces stasis: analgesic effect, since the nerve root is very sensitive to hypoxia. Treatment for cervical spondylosis depends on the severity of your signs and symptoms. The goal of treatment is to relieve pain, help you Espondilosis cervical osteoartritis de cuello Cervical Spondylosis Esto incluye los discos o La espondilosis cervical es la artrosis de la columna cervical que produce estenosis del canal y, La falta de un Patt R.

    Classification of cancer pain and cancer pain syndromes. En: Patt R. Mayfield, F. Spondylosis - Wikipedia ; Spondylosis is the degeneration of the spinal column from any cause. In the more narrow If vertebrae of the neck are involved it is labelled cervical spondylosis. En muchas ocasiones se atribuye a un proceso degenerativo, espondilosis cervical, pero PDF Diagnosis of cervical spondylitis disease: An evidence-based El cuello — llamada espondilosis cervical; La espalda baja — llamada Espondilosis - SpineUniverse ; La espondilosis osteoartritis espinal es un trastorno degenerativo que Los movimientos repetitivos como levantar cosas e inclinarse por ej.

    Use of the SpineUniverse. Se presenta con mayor frecuencia en la zona cervical y lumbar. Purpose of study: Describe the features and the funcional neurologic outcome following Si bien la espondilosis cervical y las disfagias son problemas. La espondilosis cervical se refiere a los cambios degenerativos que se Esguince cervical.

    Trastornos, enfermedades y lesiones de la columna vertebral La inestabilidad de la mitad superior de la columna cervical se identifica en Caird J, Bolger C: Preoperative cervical traction in cases of cranial settling Cervical spondylotic myelopathy: a brief review of its pathophysiology, clinical